Academy of Pharmaceutical Sciences

Symposium on the Digital Design of Drug Products

1st July 2016, Michael Sadler building, room LG19, University of Leeds

The design of new medicinal products is a risky and lengthy process. Current approaches utilise a make and test philosophy to understand processing risk. This requires large amounts of materials and knowledge is often limited by short development timelines and availability of input materials.

Hence formulations are often developed that merely accommodate variability in drug substance rather than making it an opportunity and thus a heavily over-engineered formulation and process can be produced.

The area of digital design has the opportunity to revolutionise the development and manufacturing of new medicines by utilising both mechanistic and big data approaches to produce holistic models for our processes. This will allow optimal processes and materials to be produced which will permit more rapid development and result in improved robustness of manufacturing processes.

This event brings together the concept of materials engineering with state of the art knowledge around modelling of materials and processes. It will provide information around initiatives in the pharmaceutical arena where data sharing is helping to produce better guidelines for processes. An opportunity will also be provided to learn about the recently £24M funded ADDoPT (Advanced Digital Design on Pharmaceutical Therapeutics) project which is aimed to provide new tools to the industry in the area of materials manufacture and processing.

The meeting is organised by the Academy of Pharmaceutical Sciences but is kindly facilitated by BACG and CGOM. It is a must attend for scientists and leaders in the pharmaceutical development and manufacturing sector as well as an opportunity for other manufacturing industries to learn about new developments that could be adopted on their processes.

For more details please contact

Richard.a.storey@astrazeneca.comC.Y.Ma@Leeds.ac.uk

Registration for the APS Symposium is now open. Register here.

On Thursday evening, before the APS Symposium, Tommy Dolan will be giving an evening lecture on “The Future of Medicines Manufacture: Towards Digital Design”. The Conference dinner will also be taking place on Thursday evening.

Expressions of interest for the evening lecture series will be opened closer to the event but the conference dinner and accommodation at the University of Leeds can be booked in addition to your APS registration.

Friday 1st July – APS Symposium

09:30

10:00

Registration & Refreshments

10:00

10:05

Welcome – Richard Storey, AstraZeneca/APS Treasurer

10:05

10:45

Session Chair: Richard Storey, AstraZeneca

Keynote #1 – Calvin Sun, University of Minnesota

The Materials Science Tetrahedron – The Academic Vision

Invited modelling presentations

10:45

11:15

Mojtaba Ghadiri, University of Leeds

Particle breakage modelling

11:15

11:45

Jim Litster, University of Sheffield

Wet granulation experimental and modelling

11:45

12:15

James Elliott, University of Cambridge

Compaction modelling (and DEM solution on DEM modelling)

12:15

13:20

Lunch

13:20

13:50

Session Chair: Robert Docherty, Pfizer

Industrial Perspective – Kendal Pitt, GlaxoSmithKline

The MCS – The Drive From Industry

13:50

14:30

Keynote #2 – Amrit Paudel, Research Centre for Pharmaceutical Engineering

Stability by Design

14:30

14:50

Refreshment Break

14:50

15:20

Richard Storey, AstraZeneca

Towards the Perfect Particle: What are the important design attributes?

15:20

16:00

Costas Pantelides, Process Systems Enterprise

ADDoPT Vision: System-based Pharmaceutics

16:00

16:30

Summary and Close